Article
Immunosurveillance of senescent cells: the bright side of the senescence program.
Biogerontology - 1 Dec 2013
Sagiv Adi, Krizhanovsky Valery
Abstract excerpt
Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to mediate tumor suppression and control the tissue damage response following short-term insults. In addition, the senescence associated-secretory phenotype (SASP), one of the most profound characteristics of the senescence program, facilitates the immunosurveillance of senescent cells. The SASP includes many chemokines,...
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