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Article

Biomarkers to identify and isolate senescent cells.

Ageing research reviews - 1 Aug 2016

Matjusaitis Mantas, Chin Greg, Sarnoski Ethan Anders, Stolzing Alexandra

Abstract excerpt

Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction. These cells can negatively affect neighbouring cells through an altered secretory phenotype: the senescence-associated secretory phenotype (SASP). The SASP induces senescence in healthy cells, promotes tumour formation and progression, and...

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PMID: 27212009
DOI: 10.1016/j.arr.2016.05.003

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