Article
FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007
Cox Marc B, Riggs Daniel L, Hessling Martin, Schumacher Felix, Buchner Johannes, Smith David F
Abstract excerpt
Functional maturation of steroid hormone receptors requires ordered assembly into a large multichaperone complex consisting of receptor monomer, an Hsp90 dimer, the p23 cochaperone, and an FK506-binding protein (FKBP) family member or alternate peptidylprolyl isomerase-related cochaperone. Previous cellular studies demonstrated that FKBP52 can potentiate receptor function. These results have been confirmed in...
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