Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.

The Journal of biological chemistry - 10 Jun 2011

Song Changcheng, Rahim Rahil T, Davey Penelope C, Bednar Filip, Bardi Giuseppe, Zhang Lily, Zhang Ning, Oppenheim Joost J, Rogers Thomas J

Abstract excerpt

We have previously shown that the μ-opioid receptor (MOR) is capable of mediating cross-desensitization of several chemokine receptors including CCR5, but the biochemical mechanism of this process has not been fully elucidated. We have carried out a series of functional and biochemical studies and found that the mechanism of MOR-induced cross-desensitization of CCR5 involves the activation of PKCζ. Inhibition of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetulus

Share to Protein Kinase C

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Share to Receptors, CCR5

Share to Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 21454526
DOI: 10.1074/jbc.M110.177303
PMCID: PMC3121462

Genes

CCR5
PDK1
CFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.PMID 21454526Read ↗

G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.Semantic proximity Read ↗

Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.Semantic proximity Read ↗

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor.Semantic proximity Read ↗

Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.Semantic proximity Read ↗

FK506-binding protein 12 modulates μ-opioid receptor phosphorylation and protein kinase C(ε)-dependent signaling by its direct interaction with the receptor.Semantic proximity Read ↗

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” AntagonistsSemantic proximity Read ↗

Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation.Semantic proximity Read ↗

Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.Semantic proximity Read ↗

Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability.Semantic proximity Read ↗

Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors.Semantic proximity Read ↗

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.Semantic proximity Read ↗

Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.