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Article

The prospect of FKBP51 as a drug target.

ChemMedChem - 1 Aug 2012

Schmidt Mathias V, Paez-Pereda Marcelo, Holsboer Florian, Hausch Felix

Abstract excerpt

The FK506 binding protein 51 (FKBP51) is best known as an Hsp90-associated co-chaperone that regulates the responsiveness of steroid hormone receptors. In human genetic association studies, FKBP51 has repeatedly been associated with emotion processing and numerous stress-related affective disorders. It has also been implicated in contributing to the glucocorticoid hyposensitivity observed in New World primates....

Topics

Animals
Antidepressive Agents
Depressive Disorder
Drug Design
Energy Metabolism
Gene Knockdown Techniques
HSP90 Heat-Shock Proteins
Humans
Ligands
Mice
Mice, Knockout
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Steroid

Tacrolimus Binding Proteins

Source

Identifiers

PMID: 22581765
DOI: 10.1002/cmdc.201200137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The prospect of FKBP51 as a drug target.PMID 22581765Read ↗

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.Semantic proximity Read ↗

The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary ImportanceSemantic proximity Read ↗

Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.Semantic proximity Read ↗

Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discoverySemantic proximity Read ↗

Selective inhibitors of the FK506-binding protein 51 by induced fit.Semantic proximity Read ↗

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.Semantic proximity Read ↗

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.Semantic proximity Read ↗

Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51Semantic proximity Read ↗

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat DietSemantic proximity Read ↗

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and HumansSemantic proximity Read ↗

Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted TherapiesSemantic proximity Read ↗

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric DiseaseSemantic proximity Read ↗

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