Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The prospect of FKBP51 as a drug target.

ChemMedChem - 1 Aug 2012

Schmidt Mathias V, Paez-Pereda Marcelo, Holsboer Florian, Hausch Felix

Abstract excerpt

The FK506 binding protein 51 (FKBP51) is best known as an Hsp90-associated co-chaperone that regulates the responsiveness of steroid hormone receptors. In human genetic association studies, FKBP51 has repeatedly been associated with emotion processing and numerous stress-related affective disorders. It has also been implicated in contributing to the glucocorticoid hyposensitivity observed in New World primates....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Depressive Disorder
Share to Drug Design

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Gene Knockdown Techniques

Share to HSP90 Heat-Shock Proteins

Share to Receptors, Steroid

Share to Tacrolimus Binding Proteins

Source

Identifiers

PMID: 22581765
DOI: 10.1002/cmdc.201200137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The prospect of FKBP51 as a drug target.PMID 22581765Read ↗

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.Semantic proximity Read ↗

The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary ImportanceSemantic proximity Read ↗

Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.Semantic proximity Read ↗

Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discoverySemantic proximity Read ↗

Selective inhibitors of the FK506-binding protein 51 by induced fit.Semantic proximity Read ↗

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.Semantic proximity Read ↗

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.Semantic proximity Read ↗

Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51Semantic proximity Read ↗

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat DietSemantic proximity Read ↗

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and HumansSemantic proximity Read ↗

Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted TherapiesSemantic proximity Read ↗

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.