Article
Sex differences in the effect of cytochrome P450 2C19 polymorphisms on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes.
Pharmacogenetics and genomics - 1 Dec 2013
Kajiwara Ayami, Saruwatari Junji, Kita Ayana, Kamihashi Ryoko, Miyagawa Haruna, Sakata Misaki, Noai Madoka, Oniki Kentaro, Yoshida Akira, Jinnouchi Hideaki, Nakagawa Kazuko
Abstract excerpt
Cytochrome P450 2C19 (CYP2C19) is expressed in human endothelial cells and catalyzes the biosynthesis of vasoprotective epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid from arachidonic acid. This study investigated the association between CYP2C19 polymorphisms and an increased risk of diabetic retinopathy (DR). A clinic-based retrospective longitudinal analysis was carried out that included 383...
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