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Article

Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes.

Diabetes - 1 Apr 2016

Porta Massimo, Toppila Iiro, Sandholm Niina, Hosseini S Mohsen, Forsblom Carol, Hietala Kustaa, Borio Lorenzo, Harjutsalo Valma, Klein Barbara E, Klein Ronald, Paterson Andrew D, Groop Per-Henrik

Abstract excerpt

The risk of long-term diabetes complications is not fully explained by diabetes duration or long-term glycemic exposure, suggesting the involvement of genetic factors. Because thiamine regulates intracellular glucose metabolism and corrects for multiple damaging effects of high glucose, we hypothesized that variants in specific thiamine transporters are associated with risk of severe retinopathy and/or severe...

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Identifiers

PMID: 26718501
DOI: 10.2337/db15-1247
PMCID: PMC4806664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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