Article
A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.
Journal of virology - 1 Dec 2013
Keller Paul W, Huang Rick K, England Matthew R, Waki Kayoko, Cheng Naiqian, Heymann J Bernard, Craven Rebecca C, Freed Eric O, Steven Alasdair C
Abstract excerpt
Retrovirus maturation involves sequential cleavages of the Gag polyprotein, initially arrayed in a spherical shell, leading to formation of capsids with polyhedral or conical morphology. Evidence suggests that capsids assemble de novo inside maturing virions from dissociated capsid (CA) protein, but the possibility persists of a displacive pathway in which the CA shell remains assembled but is remodeled....
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