Article
How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle.
Virus research - 26 Nov 2014
Lingappa Jaisri R, Reed Jonathan C, Tanaka Motoko, Chutiraka Kasana, Robinson Bridget A
Abstract excerpt
During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature capsid, and undergoes budding, release, and maturation. Here we review events involved in immature capsid assembly from the perspective of five different approaches used to study this process: mutational analysis, structural studies, assembly of purified recombinant Gag, assembly of newly translated Gag in a cell-free...
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