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Article

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.

Science (New York, N.Y.) - 29 Jul 2016

Schur Florian K M, Obr Martin, Hagen Wim J H, Wan William, Jakobi Arjen J, Kirkpatrick Joanna M, Sachse Carsten, Kräusslich Hans-Georg, Briggs John A G

Abstract excerpt

Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be blocked by maturation inhibitors (MIs), thereby abolishing infectivity. The CA (capsid) and SP1 (spacer peptide 1) region of Gag is the key regulator of assembly and maturation and is the target of MIs. We applied optimized cryo-electron tomography...

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Share to Capsid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to gag Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 27417497
DOI: 10.1126/science.aaf9620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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