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RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly

16 Jul 2015

Abstract excerpt

UNLABELLED: Human immunodeficiency virus type 1 (HIV-1) is released from infected cells in an immature, noninfectious form in which the structural polyprotein Gag is arranged in a hexameric lattice, forming an incomplete spherical shell. Maturation to the infectious form is mediated by the viral protease, which cleaves Gag at five sites, releasing the CA (capsid) protein, which forms a conical capsid encasing the...

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PMID: 26178992
DOI: 10.1128/jvi.00750-15

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