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Article

HIV-1 uncoats in the nucleus near sites of integration

24 Feb 2020

Abstract excerpt

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic DNA into the host chromosomes, yet remarkably, the timing and cellular location of uncoating is unknown. Previous studies have proposed that intact viral cores are too large to fit through nuclear pores and uncoating occurs in the cytoplasm in coordination with reverse transcription or at the nuclear envelope during nuclear...

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PMID: 32094182
DOI: 10.1073/pnas.1920631117

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