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Article

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation.

Proceedings of the National Academy of Sciences of the United States of America - 2 Oct 2018

Mattei Simone, Tan Aaron, Glass Bärbel, Müller Barbara, Kräusslich Hans-Georg, Briggs John A G

Abstract excerpt

HIV-1 maturation occurs via multiple proteolytic cleavages of the Gag polyprotein, causing rearrangement of the virus particle required for infectivity. Cleavage results in beta-hairpin formation at the N terminus of the CA (capsid) protein and loss of a six-helix bundle formed by the C terminus of CA and the neighboring SP1 peptide. How individual cleavages contribute to changes in protein structure and...

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PMID: 30217893
DOI: 10.1073/pnas.1811237115
PMCID: PMC6176557

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