Article
Determinants of the HIV-1 core assembly pathway.
Virology - 15 Aug 2011
López Claudia S, Eccles Jacob D, Still Amelia, Sloan Rachel E, Barklis Robin Lid, Tsagli Seyram M, Barklis Eric
Abstract excerpt
Based on structural information, we have analyzed the mechanism of mature HIV-1 core assembly and the contributions of structural elements to the assembly process. Through the use of several in vitro assembly assay systems, we have examined details of how capsid (CA) protein helix 1, ß-hairpin and cyclophilin loop elements impact assembly-dependent protein interactions, and we present evidence for a contribution...
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