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Article

High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation.

Journal of biomolecular screening - 1 Dec 2013

Isherwood Beverley J, Walls Rebecca E, Roberts Mark E, Houslay Thomas M, Brave Sandra R, Barry Simon T, Carragher Neil O

Abstract excerpt

Phenotypic screening seeks to identify substances that modulate phenotypes in a desired manner with the aim of progressing first-in-class agents. Successful campaigns require physiological relevance, robust screening, and an ability to deconvolute perturbed pathways. High-content analysis (HCA) is increasingly used in cell biology and offers one approach to prosecution of phenotypic screens, but challenges exist...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24108119
DOI: 10.1177/1087057113499775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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