Article
Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis.
PloS one - 1 Jan 2016
Twarog Nathaniel R, Low Jonathan A, Currier Duane G, Miller Greg, Chen Taosheng, Shelat Anang A
Abstract excerpt
Phenotypic screening through high-content automated microscopy is a powerful tool for evaluating the mechanism of action of candidate therapeutics. Despite more than a decade of development, however, high content assays have yielded mixed results, identifying robust phenotypes in only a small subset of compound classes. This has led to a combinatorial explosion of assay techniques, analyzing cellular phenotypes...
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