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Article

A computational model predicting disruption of blood vessel development.

PLoS computational biology - 1 Apr 2013

Kleinstreuer Nicole, Dix David, Rountree Michael, Baker Nancy, Sipes Nisha, Reif David, Spencer Richard, Knudsen Thomas

Abstract excerpt

Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a variety of biological pathways linked to endothelial cell (EC) behavior, extracellular matrix (ECM) remodeling and the local generation of...

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Identifiers

PMID: 23592958
DOI: 10.1371/journal.pcbi.1002996
PMCID: PMC3616981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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