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Article

Benchmarking of multivariate similarity measures for high-content screening fingerprints in phenotypic drug discovery.

Journal of biomolecular screening - 1 Dec 2013

Reisen Felix, Zhang Xian, Gabriel Daniela, Selzer Paul

Abstract excerpt

High-content screening (HCS) is a powerful tool for drug discovery being capable of measuring cellular responses to chemical disturbance in a high-throughput manner. HCS provides an image-based readout of cellular phenotypes, including features such as shape, intensity, or texture in a highly multiplexed and quantitative manner. The corresponding feature vectors can be used to characterize phenotypes and are thus...

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PMID: 24045583
DOI: 10.1177/1087057113501390

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