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Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect

1 Mar 2022

Abstract excerpt

Genetic defects in SLC26A3 (DRA), an intestinal Cl−/HCO3− exchanger, result in congenital chloride diarrhea (CLD), marked by lifelong acidic diarrhea and a high risk of inflammatory bowel disease. Slc26a3−/− mice serve as a model to understand the pathophysiology of CLD and search for treatment options. This study investigates the microbiota changes in slc26a3−/− colon, the genotype-related causes for the...

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PMID: 35230892
DOI: 10.1080/19490976.2022.2041943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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