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Article

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.

Digestive diseases (Basel, Switzerland) - 1 Jan 2012

Bauer Christian, Duewell Peter, Lehr Hans-Anton, Endres Stefan, Schnurr Max

Abstract excerpt

BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system. The cytokines IL-1β and IL-18 appear early in intestinal inflammation and their pro-forms are processed via the caspase-1-activating multiprotein complex, the Nlrp3 inflammasome. Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages...

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Identifiers

PMID: 23075874
DOI: 10.1159/000341681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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