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Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

7 Oct 2023

Abstract excerpt

Abstract Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional interactions between the intestinal microbiota and host mitochondria may modulate intestinal inflammation. We observed previously that mice deficient in the mitochondrial protein MCJ (Methylation-controlled J protein) exhibit increased susceptibility to DSS...

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PMID: 37805634
DOI: 10.1038/s41522-023-00443-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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