Article
Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors.
Cancer research - 15 Jun 1997
Souza R F, Yin J, Smolinski K N, Zou T T, Wang S, Shi Y Q, Rhyu M G, Cottrell J, Abraham J M, Biden K, Simms L, Leggett B, Bova G S, Frank T, Powell S M, Sugimura H, Young J, Harpaz N, Shimizu K, Matsubara N, Meltzer S J
Abstract excerpt
The E2F group of transcription factors transactivates genes that promote progression through the G1-S transition of the cell cycle. Members of the retinoblastoma (Rb) family of proteins bind to E2Fs and inhibit this function. E2F-4, one example of the E2F group, functions as an oncogene when transfected into nontransformed cells in vitro. On the other hand, mice that are homozygously lacking a normal E2F-1 gene...
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