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Article

A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.

The Journal of biological chemistry - 31 Mar 2006

Delfino Frank J, Stevenson Heather, Smithgall Thomas E

Abstract excerpt

The human c-fes locus encodes a non-receptor protein-tyrosine kinase implicated in myeloid, vascular endothelial, and neuronal cell differentiation. A recent analysis of the tyrosine kinome in colorectal cancer identified c-fes as one of only seven genes with consistent kinase domain mutations. Although four mutations were identified (M704V, R706Q, V743M, S759F), the consequences of these mutations on Fes kinase...

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PMID: 16455651
DOI: 10.1074/jbc.M507331200

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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