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Article

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2007

Tazawa Hiroshi, Tsuchiya Naoto, Izumiya Masashi, Nakagama Hitoshi

Abstract excerpt

Accumulating evidence suggests a role for microRNAs in human carcinogenesis as novel types of tumor suppressors or oncogenes. However, their precise biological role remains largely elusive. In the present study, we aimed to identify microRNA species involved in the regulation of cell proliferation. Using quantitative RT-PCR analysis, we demonstrated that miR-34a was highly up-regulated in a human colon cancer...

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Identifiers

PMID: 17875987
DOI: 10.1073/pnas.0707351104
PMCID: PMC2000550

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