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Article

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding.

Molecular cancer research : MCR - 1 May 2021

Lanauze Claudia B, Sehgal Priyanka, Hayer Katharina, Torres-Diz Manuel, Pippin James A, Grant Struan F A, Thomas-Tikhonenko Andrei

Abstract excerpt

About 10% to 30% of patients with colorectal cancer harbor either loss of or missense mutations in SMAD4, a critical component of the TGFβ signaling pathway. The pathophysiologic function of missense mutations in Smad4 is not fully understood. They usually map to the MH2 domain, specifically to residues that are involved in heterodimeric complex formation with regulatory Smads (such as Smad2/3) and ensuing...

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Identifiers

PMID: 33608451
DOI: 10.1158/1541-7786.MCR-20-0721
PMCID: PMC8137583

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