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Article

"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary.

Free radical biology & medicine - 1 Nov 2008

Zielonka Jacek, Kalyanaraman B

Abstract excerpt

In a recent publication (K. Ishikawa et al., 2008, Science320, 661-664), the authors described how replacing the endogenous mitochondrial DNA (mtDNA) in a weakly metastatic mouse tumor cell line with mtDNA from a highly metastatic cell line enhanced tumor progression through enhanced production of reactive oxygen species (ROS). The authors attributed the transformation from a low-metastatic cell line to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18789385
DOI: 10.1016/j.freeradbiomed.2008.07.025
PMCID: PMC3595710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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