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Article

Role of the locus coeruleus in enhanced orexin A-induced spontaneous physical activity in obesity-resistant rats.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Dec 2013

Teske Jennifer A, Perez-Leighton Claudio E, Billington Charles J, Kotz Catherine M

Abstract excerpt

Orexin/hypocretin terminals innervate noradrenergic locus coeruleus (LC) neurons that project to the prefrontral cortex, which may influence spontaneous physical activity (SPA) and energy balance. Obesity-resistant (OR) rats have higher orexin receptors (OXR) mRNA in the LC and other brain regions, as well as lower adiposity compared with obese rats. These findings led us to hypothesize that orexin activity in...

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Identifiers

PMID: 24089383
DOI: 10.1152/ajpregu.00229.2013
PMCID: PMC3882567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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