Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Oct 2006

Teske J A, Levine A S, Kuskowski M, Levine J A, Kotz C M

Abstract excerpt

Selectively-bred obesity-resistant [diet resistant (DR)] rats weigh less than obesity-prone [diet-induced obese (DIO)] rats, despite comparable daily caloric intake, suggesting phenotypic energy expenditure differences. Human data suggest that obesity is maintained by reduced ambulatory or spontaneous physical activity (SPA). The neuropeptide orexin A robustly stimulates SPA. We hypothesized that DR rats have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Energy Intake
Share to Hypothalamus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Neuropeptides

Share to Orexin Receptors

Share to Orexins

Share to Receptors, G-Protein-Coupled

Share to Receptors, Neuropeptide

Source

Identifiers

PMID: 16763079
DOI: 10.1152/ajpregu.00536.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant rats.PMID 16763079Read ↗

Role of the locus coeruleus in enhanced orexin A-induced spontaneous physical activity in obesity-resistant rats.Semantic proximity Read ↗

Effect of acute and chronic caloric restriction and metabolic glucoprivation on spontaneous physical activity in obesity-prone and obesity-resistant rats.Semantic proximity Read ↗

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset.Semantic proximity Read ↗

Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet.Semantic proximity Read ↗

F-DIO obesity-prone rat is insulin resistant before obesity onset.Semantic proximity Read ↗

Colony maintenance and the behavioral and physiological characteristics of selectively bred obesity prone and obesity resistant ratsSemantic proximity Read ↗

Spontaneous physical activity protects against fat mass gain.Semantic proximity Read ↗

Differential stress responsivity in diet-induced obese and resistant rats.Semantic proximity Read ↗

Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?Semantic proximity Read ↗

Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2.Semantic proximity Read ↗

Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats.Semantic proximity Read ↗

Physiological difference between dietary obesity-susceptible and obesity-resistant Sprague Dawley rats in response to moderate high fat diet.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.