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Article

Ventromedial nucleus neurons are less sensitive to leptin excitation in rats bred to develop diet-induced obesity.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Mar 2009

Irani Boman G, Le Foll Christelle, Dunn-Meynell Ambrose A, Levin Barry E

Abstract excerpt

Maternal obesity accentuates offspring obesity in dams bred to develop diet-induced obesity (DIO) on a 31% fat, high energy (HE) diet but has no effect on offspring of diet-resistant (DR) dams. Only DIO dams became obese on HE diet when they and DR dams were fed 5% fat chow or HE diets throughout gestation and lactation. Leptin sensitivity of dissociated arcuate (ARC) and ventromedial (VMN) hypothalamic nucleus...

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Source

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Identifiers

PMID: 19118094
DOI: 10.1152/ajpregu.90842.2008
PMCID: PMC2665853

Genes

ARC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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