Article
Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms.
Peptides - 1 Feb 2017
Tang Shi, Huang Weiwei, Lu Shanshan, Lu Lili, Li Guohua, Chen Xu, Liu Xiaomin, Lv Xin, Zhao Zhangning, Duan Ruisheng, Du Yifeng, Tang Jiyou
Abstract excerpt
Orexins, also known as hypocretins, play a regulatory role in the sleep-wake cycle by activating orexin receptors. Previous animal studies have shown that sleep deprivation can elevate orexinergic peptide levels. However, the relationship between insomnia disorder and orexin-A levels in humans has not been explored. In the current study, we examined plasma orexin-A levels in patients with insomnia disorder and in...
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