Article
Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats.
Neuroscience - 15 Dec 2010
Alsiö J, Olszewski P K, Norbäck A H, Gunnarsson Z E A, Levine A S, Pickering C, Schiöth H B
Abstract excerpt
The nucleus accumbens (NAcc) mediates feeding reward; its activity reflects tastants' hedonic value. NAcc dopamine guides immediate responses to reward, however, its involvement in establishing long-term responses after a period of exposure to palatable foods has not been defined. Furthermore, reward-driven overeating propels weight increase, but the scale of weight gain depends on animals' obesity-prone (OP) or...
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