Article
Mutational specificity of alkylating agents and the influence of DNA repair.
Environmental and molecular mutagenesis - 1 Jan 1990
Horsfall M J, Gordon A J, Burns P A, Zielenska M, van der Vliet G M, Glickman B W
Abstract excerpt
Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act via an alkyldiazonium cation, such as the N-nitroso compounds, preferentially generate G: C = greater than A:T...
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