Mutational specificity of alkylating agents and the influence of DNA repair.

doi:10.1002/em.2850150208

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Article

Mutational specificity of alkylating agents and the influence of DNA repair.

Environmental and molecular mutagenesis - 1 Jan 1990

Horsfall M J, Gordon A J, Burns P A, Zielenska M, van der Vliet G M, Glickman B W

Abstract excerpt

Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act vi...

Topics

Alkylating Agents
Base Composition
Base Sequence
DNA
DNA Repair
DNA, Bacterial
Escherichia coli
Molecular Sequence Data
Mutation
Structure-Activity Relationship
Ultraviolet Rays

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