Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases.

doi:10.1016/0027-5107(90)90153-u

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Article

Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases.

Mutation research - 1 Jan 2000

Swann P F

Abstract excerpt

The carcinogenic and mutagenic N-nitroso compounds produce GC to AT and TA to GC transition mutations because they alkylate O6 of guanine and O4 of thymine. It has been generally assumed that these mutations occur because O6-alkylguanine forms a stable mispair with thymine and O4-alkylthymine for...

Topics

Alkylation
Base Composition
Base Sequence
DNA
Guanine
Molecular Sequence Data
Molecular Structure
Mutation
Thymine

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