The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems.

doi:10.1093/carcin/17.5.895

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Article

The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems.

Carcinogenesis - 1 May 1996

Loechler E L

Abstract excerpt

Usually, a particular mutagen/carcinogen forms adducts at many sites in DNA, making it impossible to determine which type of adduct causes which mutation and why. Adduct site-specific mutagenesis studies, in which a single adduct is built into a vector, can be used to overcome this problem. The a...

Topics

Base Sequence
Carcinogens
DNA Adducts
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation

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