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Article

Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs.

Molecular immunology - 1 Jan 2009

Steele Edward J

Abstract excerpt

The DNA sequence data of the somatic hypermutation (SHM) field published since 1984 has been critically reviewed. The analysis has revealed three strand biased mutation signatures. The first concerns the mutations generated at G:C base pairs in mice genetically deficient in uracil-DNA glycosylase and MSH2-MSH6-mediated mismatch repair. Such mice display the AID deaminase footprint and here C mutations exceed G...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Somatic Hypermutation, Immunoglobulin

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Source

Identifiers

PMID: 19062097
DOI: 10.1016/j.molimm.2008.10.021

Genes

MSH2
MSH6
NTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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