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Article

Discrimination of mutagenic intermediates derived from alkylating agents by mutational patterns generated in Escherichia coli.

Carcinogenesis - 1 Jul 1991

Elespuru R K, Stupar L L, Gordon J A

Abstract excerpt

Reactive intermediates (ultimate mutagens/carcinogens) generated by alkylating agents are unstable and difficult to characterize by chemical means. We have used a genetic system to distinguish the in vivo interactions of eight carcinogenic methylating agents and five ethylating agents by the patterns of induced mutations at different target sites in Escherichia coli WU3610. For this multiple locus assay, target...

Topics

Alkylating Agents
Chromosome Mapping
DNA, Bacterial
Dose-Response Relationship, Drug
Escherichia coli
Mutagens
Mutation
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2070480
DOI: 10.1093/carcin/12.7.1161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2070480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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