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Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

1 Nov 2002

Abstract excerpt

Alkylating agents are a structurally diverse group of compounds that cause a wide range of biological effects, including cell death, mutation and cancer. DNA damaged by these agents contains widely different amounts of 12 alkylated purines/pyrimidines and two phosphotriester isomers. The biological effects appear to be mediated predominantly by attack at the O(6) position of guanine. DNA extracted from various...

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Identifiers

PMID: 12435845
DOI: 10.1093/mutage/17.6.483

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