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Article

Mechanism of mutagenesis by O6-methylguanine.

Nature - 1 Jan 2000

Eadie J S, Conrad M, Toorchen D, Topal M D

Abstract excerpt

O6-methylguanine (O6meG) lesions of double-stranded DNA have been associated with mutation and neoplastic transformation. These lesions can, in principle, be produced by at least three different mechanisms: direct alkylation of G X C base pairs in double-stranded DNA; alkylation of guanine residues in single-stranded regions of DNA associated with replication forks; and alkylation of the DNA precursor pool...

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PMID: 6322009
DOI: 10.1038/308201a0

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