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Article

Mechanism of mutagenesis by O6-methylguanine.

Nature - 1 Jan 2000

Eadie J S, Conrad M, Toorchen D, Topal M D

Abstract excerpt

O6-methylguanine (O6meG) lesions of double-stranded DNA have been associated with mutation and neoplastic transformation. These lesions can, in principle, be produced by at least three different mechanisms: direct alkylation of G X C base pairs in double-stranded DNA; alkylation of guanine residu...

Topics

Base Sequence
Coliphages
DNA Repair
DNA Replication
DNA Restriction Enzymes
DNA, Viral
Escherichia coli
Genotype
Guanine
Mutagenicity Tests
Mutagens
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 6322009
DOI: 10.1038/308201a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6322009-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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