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Article

Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine.

Nucleic acids research - 1 Nov 2012

Bhamra Inder, Compagnone-Post Patricia, O'Neil Ian A, Iwanejko Lesley A, Bates Andrew D, Cosstick Richard

Abstract excerpt

8-Nitro-2'-deoxyguanosine (8-nitrodG) is a relatively unstable, mutagenic lesion of DNA that is increasingly believed to be associated with tissue inflammation. Due to the lability of the glycosidic bond, 8-nitrodG cannot be incorporated into oligodeoxynucleotides (ODNs) by chemical DNA synthesis and thus very little is known about its physicochemical properties and base-pairing preferences. Here we describe the...

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Identifiers

PMID: 22965127
DOI: 10.1093/nar/gks799
PMCID: PMC3505964

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Source receipt: pubmed, retrieved 7 Sept 2026.

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