N-methyl-N'-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis.

doi:10.1016/0027-5107(90)90154-v

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Article

N-methyl-N'-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis.

Mutation research - 1 Jan 2000

Gordon A J, Burns P A, Glickman B W

Abstract excerpt

Our approach to the study of how the molecular nature of DNA modulates the behavior of mutational sites involves the characterisation of distributions of mutations. The Escherichia coli lacI genetic/M13 cloning system allows the comparison of base substitution frequencies at a large number of sit...

Topics

Alkylation
Base Composition
Base Sequence
DNA, Bacterial
Escherichia coli
Methylnitronitrosoguanidine
Molecular Sequence Data
Mutagenesis
Mutation

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