Article
Importance of hematocrit for a tacrolimus target concentration strategy.
European journal of clinical pharmacology - 1 Jan 2014
Størset Elisabet, Holford Nick, Midtvedt Karsten, Bremer Sara, Bergan Stein, Åsberg Anders
Abstract excerpt
PURPOSE: To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients. METHODS: Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough concentrations in 44 patients measured during the first 70 days after transplantation (1,546 tacrolimus whole blood concentrations) were analyzed. Population pharmacokinetic modeling was performed...
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