Article
A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach.
Clinical pharmacokinetics - 1 Aug 2017
Andreu Franc, Colom Helena, Elens Laure, van Gelder Teun, van Schaik Ronald H N, Hesselink Dennis A, Bestard Oriol, Torras Joan, Cruzado Josep M, Grinyó Josep M, Lloberas Nuria
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the CYP3A5 and CYP3A4 genes have been reported to be an important cause of variability in the pharmacokinetics of tacrolimus in renal transplant patients. The aim of this study was to merge all of the new genetic information available with tacrolimus pharmacokinetics to generate a more robust population model with data from renal transplant recipients....
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