Article
[Pharmacogenetics of tacrolimus: from bench to bedside?].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - 1 Jan 2014
Tavira Beatriz, Díaz-Corte Carmen, Coronel Diego, Ortega Francisco, Coto Eliecer
Abstract excerpt
Tacrolimus (FK-506) is an immunosuppressant widely used to prevent kidney transplant rejection. Patients receive an initial standard dose and tacrolimus levels are measured in blood. If necessary, the dose is adjusted to reach a blood concentration within the accepted range. There is great interindividual variability in the dose required to achieve the target blood level, and many patients require multiple...
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