Article
The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients.
Clinical pharmacokinetics - 1 Sept 2016
Prytuła Agnieszka A, Cransberg Karlien, Bouts Antonia H M, van Schaik Ron H N, de Jong Huib, de Wildt Saskia N, Mathôt Ron A A
Abstract excerpt
BACKGROUND: The aim of this study was to develop a population pharmacokinetic model of tacrolimus in paediatric patients at least 1 year after renal transplantation and simulate individualised dosage regimens. PATIENTS AND METHODS: We included 54 children with median age of 11.1 years (range 3.8-18.4 years) with 120 pharmacokinetic profiles performed over 2 to 4 h. The pharmacokinetic analysis was performed using...
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