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Article

Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.

Histopathology - 1 Dec 2017

Saldarriaga Joan, Bisig Bettina, Couchy Gabrielle, Castain Claire, Zucman-Rossi Jessica, Balabaud Charles, Sempoux Christine, Bioulac-Sage Paulette

Abstract excerpt

The identification of hepatocellular adenoma (HCA) with mutation in exon 3 of the CTNNB1 gene encoding for β-catenin is clinically relevant due to a higher risk of malignant transformation. Inflammatory HCA (IHCA) can exhibit β-catenin activation (β-IHCA). We report two cases with multiple IHCA in which focal β-catenin activation has been found in one of the IHCA. In both cases, the diagnosis of IHCA was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28618047
DOI: 10.1111/his.13283

Genes

CRP
CTNNB1

Provenance

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