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Article

Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.

Hepatology (Baltimore, Md.) - 1 Dec 2016

Rebouissou Sandra, Franconi Andrea, Calderaro Julien, Letouzé Eric, Imbeaud Sandrine, Pilati Camilla, Nault Jean-Charles, Couchy Gabrielle, Laurent Alexis, Balabaud Charles, Bioulac-Sage Paulette, Zucman-Rossi Jessica

Abstract excerpt

CTNNB1 mutations activating ß-catenin are frequent somatic events in hepatocellular carcinoma (HCC) and adenoma (HCA), particularly associated with a risk of malignant transformation. We aimed to understand the relationship between CTNNB1 mutation types, tumor phenotype, and level of ß-catenin activation in malignant transformation. To this purpose, CTNNB1 mutation spectrum was analyzed in 220 HCAs, 373 HCCs, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27177928
DOI: 10.1002/hep.28638

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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