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Article

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.

Hepatology (Baltimore, Md.) - 1 Jun 2016

Matter Matthias S, Marquardt Jens U, Andersen Jesper B, Quintavalle Cristina, Korokhov Nikolay, Stauffer Jim K, Kaji Kosuke, Decaens Thomas, Quagliata Luca, Elloumi Fathi, Hoang Tanya, Molinolo Alfredo, Conner Elizabeth A, Weber Achim, Heikenwalder Mathias, Factor Valentina M, Thorgeirsson Snorri S

Abstract excerpt

UNLABELLED: The majority of hepatocellular carcinoma develops in the background of chronic liver inflammation caused by viral hepatitis and alcoholic or nonalcoholic steatohepatitis. However, the impact of different types of chronic inflammatory microenvironments on the phenotypes of tumors generated by distinct oncogenes is largely unresolved. To address this issue, we generated murine liver tumors by...

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Identifiers

PMID: 26844528
DOI: 10.1002/hep.28487
PMCID: PMC4874846

Genes

CAT
DDC
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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