Article
Hepatocellular Adenomas: Morphology and Genomics.
Gastroenterology clinics of North America - 1 Jun 2017
Bioulac-Sage Paulette, Sempoux Christine, Balabaud Charles
Abstract excerpt
Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin-activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly...
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