Article
Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.
Human pathology - 1 Apr 2017
Sempoux Christine, Bisig Bettina, Couchy Gabrielle, Balabaud Charles, Zucman-Rossi Jessica, Bioulac-Sage Paulette
Abstract excerpt
In 1984, a 24-year-old woman underwent a right hepatectomy after a 17-cm nodule, diagnosed as a hepatocellular adenoma with some atypia. The resection was incomplete. Follow-up was interrupted. In 1996, a computed tomographic scan revealed a large multifocal hepatocellular carcinoma confirmed on biopsies. The patient died the same year. We reviewed these nodules using immunohistochemistry and gene sequencing....
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