Conditional mutations occur predominantly in highly conserved residues of RNA polymerase II subunits.

doi:10.1128/mcb.10.3.1270-1275.1990

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Article

Conditional mutations occur predominantly in highly conserved residues of RNA polymerase II subunits.

Molecular and cellular biology - 1 Mar 1990

Scafe C, Martin C, Nonet M, Podos S, Okamura S, Young R A

Abstract excerpt

Conditional mutations in the Saccharomyces cerevisiae RNA polymerase II large subunit, RPB1, were obtained by introducing a mutagenized RPB1 plasmid into yeast cells, selecting for loss of the wild-type RPB1 gene, and screening the cells for heat or cold sensitivity. Sequence analysis of 10 condi...

Topics

Amino Acid Sequence
Molecular Sequence Data
Mutation
RNA Polymerase II
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Temperature

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